Hypoxia-driven immunosuppression contributes to the pre-metastatic niche
نویسندگان
چکیده
Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-metastatic niches by recruiting CD11b+/Ly6Cmed/Ly6G+ myeloid cells and suppressing natural killer cell functions.
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1 Cancer Genomics and Genetics Laboratory, 3 Cancer Immunology Program, and 6 Metastasis Research Group, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia. 2 Department of Pathology, 5 Sir Peter MacCallum Department of Oncology, 7 Department of Biochemistry, The University of Melbourne, Parkville, Victoria 3010, Australia. 4 Monash Institute of Pharmaceu...
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